Description

(3R)-1-Boc-3-Azido-Pyrrolidine is a high-purity, chiral building block essential for advanced pharmaceutical synthesis and chemical research. This compound serves as a key intermediate in the construction of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and novel chemical entities. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in medicinal chemistry, process development, and the synthesis of nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of drug candidates, particularly those containing pyrrolidine scaffolds.
• Peptidomimetic Research: Used in the design and synthesis of peptidomimetics and constrained peptides to modulate biological activity.
• Click Chemistry: The azido group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and material science applications.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective synthesis to introduce defined stereocenters.
• API Process Development: Integral to route scouting and scale-up processes for the commercial manufacturing of complex APIs.
• Chemical Biology Probes: Facilitates the creation of tagged molecules for studying biological pathways and target engagement.

Basic Information

Product Name	(3R)-1-Boc-3-Azido-Pyrrolidine
CAS No.	143700-04-3
Molecular Formula	C9H16N4O2
Molecular Weight	212.25 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-3-azido-(3R)-pyrrolidine; (R)-1-Boc-3-azidopyrrolidine; (R)-3-Azido-1-Boc-pyrrolidine; tert-Butyl (3R)-3-azidopyrrolidine-1-carboxylate; (R)-1-N-Boc-3-azidopyrrolidine; (3R)-1-(tert-Butoxycarbonyl)-3-azidopyrrolidine; 1-Boc-3-azido-(R)-pyrrolidine; Azido-Boc-pyrrolidine (R)
EINECS	Contact for details

Quality Control

Our (3R)-1-Boc-3-Azido-Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.