Description

1-(4-Aminophenyl)-3-Methylcarbamoyl-4-Methyl-7,8-Methylenedioxy-3,4-Dihydro-5H-2,3-Benzodiazepine is a high-purity, structurally complex benzodiazepine derivative serving as a critical advanced intermediate in pharmaceutical research and development. Its unique fused ring system with an aminophenyl and methylcarbamoyl moiety makes it a valuable scaffold for synthesizing novel bioactive compounds. This product is essential for medicinal chemists and R&D laboratories focused on developing new therapeutic agents targeting the central nervous system and other disease areas.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel benzodiazepine-based drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold in structure-activity relationship (SAR) studies and lead optimization programs.
• Preclinical Development: Serves as a starting material for producing compounds for pharmacological screening and toxicology studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in API manufacturing.
• Academic Research: Employed in university and institutional labs for studying heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	1-(4-Aminophenyl)-3-Methylcarbamoyl-4-Methyl-7,8-Methylenedioxy-3,4-Dihydro-5H-2,3-Benzodiazepine
CAS No.	143692-18-6
Molecular Formula	C19H20N4O3
Molecular Weight	352.39 g/mol
Synonyms	1-(4-Aminophenyl)-3-(methylcarbamoyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine; 4-Methyl-1-(4-aminophenyl)-7,8-methylenedioxy-3-(N-methylcarbamoyl)-3,4-dihydro-5H-2,3-benzodiazepine; 3,4-Dihydro-1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3-(N-methylaminocarbonyl)-5H-2,3-benzodiazepine; GYKI-52466 dihydrochloride precursor; 2,3-Benzodiazepine derivative; CAS 143692-18-6
EINECS	Contact for details

Quality Control

Our 1-(4-Aminophenyl)-3-Methylcarbamoyl-4-Methyl-7,8-Methylenedioxy-3,4-Dihydro-5H-2,3-Benzodiazepine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.