Description

n-(T-Boc)-3-Phenyl Isoserine Ethyl Ester is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block, enabling the precise construction of complex molecular architectures. It is primarily required by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of Taxol (Paclitaxel) side chains and other complex anti-cancer agents.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate the phenylisoserine moiety with orthogonal protection.
• Protease Inhibitor Development: Serves as a core structural element in the design and synthesis of protease inhibitors.
• Chemical Biology Research: Employed in the preparation of labeled compounds, molecular probes, and for structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric transformations to access enantiomerically pure products.
• Custom Synthesis & Contract Manufacturing: A vital raw material for CDMOs (Contract Development and Manufacturing Organizations) producing specialized fine chemicals on scale.

Basic Information

Product Name	n-(T-Boc)-3-Phenyl Isoserine Ethyl Ester
CAS No.	143527-75-7
Molecular Formula	C₁₈H₂₇NO₆
Molecular Weight	353.41 g/mol
Synonyms	(2R,3S)-3-Phenylisoserine Ethyl Ester N-t-Butoxycarbonyl Derivative; Ethyl (2R,3S)-3-Phenyl-2-[(tert-butoxycarbonyl)amino]-3-hydroxypropanoate; N-Boc-3-Phenylisoserine Ethyl Ester; N-(tert-Butoxycarbonyl)-3-phenylisoserine Ethyl Ester; (2R,3S)-N-Boc-Phenylisoserine Ethyl Ester; Taxol Side Chain Intermediate; BOC-Phe(3-OH)-OEt; 143527-75-7
EINECS	Contact for details

Quality Control

Our n-(T-Boc)-3-Phenyl Isoserine Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed under inert atmosphere (e.g., nitrogen) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.