Description

tert-Butyl 8-Oxo-5-Azaspiro[2.5]Octane-5-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and lactam structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and antiviral drugs. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in cutting-edge medicinal chemistry and process development.

Application

• Key Intermediate in API Synthesis: Serves as a crucial building block for the production of novel pharmaceuticals, especially those targeting neurological disorders.
• Medicinal Chemistry Research: Used in the discovery and optimization of new drug candidates, leveraging its constrained spirocyclic scaffold.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for commercial drug manufacturing.
• Precursor to Bioactive Molecules: A versatile starting material for synthesizing libraries of compounds for high-throughput screening and biological evaluation.

Basic Information

Product Name	tert-Butyl 8-Oxo-5-Azaspiro[2.5]Octane-5-Carboxylate
CAS No.	143306-64-3
Molecular Formula	C12H19NO3
Molecular Weight	225.28 g/mol
Synonyms	5-Azaspiro[2.5]octane-5-carboxylic acid, 8-oxo-, 1,1-dimethylethyl ester; 8-Oxo-5-azaspiro[2.5]octane-5-carboxylic acid tert-butyl ester; tert-Butyl 8-oxo-5-azaspiro[2.5]octane-5-carboxylate; Boc-8-oxo-5-azaspiro[2.5]octane; 5-Boc-8-oxo-5-azaspiro[2.5]octane; 143306-64-3; tert-Butyl 8-oxo-5-azaspiro[2.5]octan-5-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Oxo-5-Azaspiro[2.5]Octane-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.