Description

(R)-1-((R)-2,2-Dimethyl-1,3-Dioxolan-4-Yl)-3-Ethoxy-2,2-Difluoro-3-Oxopropyl Benzoate is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly those requiring specific stereochemistry for efficacy. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in developing novel therapeutics.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of complex, stereospecific Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Used in catalytic and stoichiometric asymmetric reactions to construct molecules with defined three-dimensional structures.
• Medicinal Chemistry Research: A valuable scaffold for drug discovery and lead optimization programs targeting new biological pathways.
• Process Chemistry Development: Serves as a critical starting material for scaling up synthetic routes under Current Good Manufacturing Practice (cGMP) conditions.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals where precise fluorine substitution and stereochemistry are required.

Basic Information

Product Name	(R)-1-((R)-2,2-Dimethyl-1,3-Dioxolan-4-Yl)-3-Ethoxy-2,2-Difluoro-3-Oxopropyl Benzoate
CAS No.	143234-90-6
Molecular Formula	C₁₇H₂₀F₂O₆
Molecular Weight	358.34 g/mol
Synonyms	(R)-1-[(R)-2,2-Dimethyl-1,3-dioxolan-4-yl]-3-ethoxy-2,2-difluoro-3-oxopropyl benzoate; Benzoic acid, (R)-1-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-ethoxy-2,2-difluoro-3-oxopropyl ester; (R,R)-Difluorinated dioxolane benzoate ester; Chiral difluoro keto ester intermediate; 143234-90-6; (R,R)-143234-90-6
EINECS	Contact for details

Quality Control

Our production of (R)-1-((R)-2,2-Dimethyl-1,3-Dioxolan-4-Yl)-3-Ethoxy-2,2-Difluoro-3-Oxopropyl Benzoate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high enantiomeric excess (ee) and chemical purity suitable for advanced synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.