Description

(S)-(-)-n-Methoxymethyl-n-(Trimethylsilyl)Methyl-1-Phenylethylamine is a high-value, chiral amine derivative featuring both methoxymethyl and trimethylsilylmethyl protecting groups. This compound is a critical chiral building block and ligand precursor in advanced organic synthesis, prized for its ability to induce stereoselectivity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for the asymmetric synthesis of active pharmaceutical ingredients (APIs) and complex natural products.

Application

• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand precursor in stereoselective carbon-carbon bond-forming reactions, such as alkylations and aldol additions.
• Pharmaceutical Intermediates: Serves as a key building block in the multi-step synthesis of chiral drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Catalyst Development: Used in the preparation of novel chiral catalysts and ligands for transition metal-catalyzed asymmetric transformations.
• Methodology Research: A valuable reagent in academic and industrial research for developing new synthetic methodologies involving silicon-based protecting groups and chiral induction.
• Fine Chemical Production: Integral to the custom synthesis of high-value, enantiomerically pure fine chemicals and specialty materials.

Basic Information

Product Name	(S)-(-)-n-Methoxymethyl-n-(Trimethylsilyl)Methyl-1-Phenylethylamine
CAS No.	143140-08-3
Molecular Formula	C15H27NOSi
Molecular Weight	265.47 g/mol
Synonyms	(S)-(-)-N-Methoxymethyl-N-[(trimethylsilyl)methyl]-1-phenylethylamine; (S)-N-Methoxymethyl-N-[(trimethylsilyl)methyl]-α-methylbenzylamine; (S)-N-[(Trimethylsilyl)methyl]-N-(methoxymethyl)-1-phenylethylamine; (S)-N-MOM-N-TMSM-PEA; (S)-Methoxymethyl(trimethylsilylmethyl)amine derivative; Chiral N,N-dialkylbenzylamine; Chiral silylated amine auxiliary
EINECS	Contact for details

Quality Control

Our (S)-(-)-n-Methoxymethyl-n-(Trimethylsilyl)Methyl-1-Phenylethylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including chiral purity assessment by HPLC, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee batch-to-batch consistency and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.