Description

Ethyl n-Boc-Piperidine-4-Carboxylate is a high-purity, protected amino acid ester derivative, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in providing a versatile and reactive piperidine scaffold with orthogonal protecting groups, enabling precise and efficient construction of complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs), novel drug candidates, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of piperidine-based drug molecules, including receptor antagonists, enzyme inhibitors, and central nervous system (CNS) active compounds.
• Peptidomimetics & Constrained Peptide Synthesis: Used to introduce rigid, conformationally restricted piperidine units into peptide backbones to enhance stability, bioavailability, and biological activity.
• Combinatorial Chemistry & Library Synthesis: An ideal building block for generating diverse compound libraries for high-throughput screening in drug discovery programs.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides that incorporate functionalized piperidine motifs.
• Catalyst & Ligand Development: Serves as a precursor for creating novel chiral catalysts and ligands used in asymmetric synthesis.
• Academic & R&D Laboratories: Used in methodological research and the development of new synthetic routes involving amine protection/deprotection strategies.

Basic Information

Product Name	Ethyl n-Boc-Piperidine-4-Carboxylate
CAS No.	142851-03-4
Molecular Formula	C13H23NO4
Molecular Weight	257.33 g/mol
Synonyms	1-Boc-4-(Ethoxycarbonyl)piperidine; Ethyl 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylate; 4-(Ethoxycarbonyl)-1-piperidinecarboxylic acid tert-butyl ester; 1-N-Boc-4-Carbethoxypiperidine; tert-Butyl 4-(ethoxycarbonyl)piperidine-1-carboxylate; 4-Carbethoxy-1-piperidinecarboxylic acid tert-butyl ester; Ethyl 1-Boc-piperidine-4-carboxylate; N-Boc-4-(Ethoxycarbonyl)piperidine
EINECS	Contact for details

Quality Control

Our Ethyl n-Boc-Piperidine-4-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.