Description

Methyl 2,3,4-Tri-o-Benzyl-β-D-Glucuronic Acid, Benzyl Ester is a protected glucuronic acid derivative, a crucial synthetic intermediate in carbohydrate and medicinal chemistry. Its primary value lies in providing a versatile, reactive scaffold for the controlled synthesis of complex glycoconjugates and other bioactive molecules. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly for developing prodrugs, targeted drug delivery systems, and advanced glycosylation methodologies.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of glucuronide prodrugs, which can improve drug solubility, stability, and targeted release.
• Glycoconjugate Synthesis: Used in the preparation of complex oligosaccharides, glycopeptides, and glycolipids for biological studies and therapeutic development.
• Medicinal Chemistry Research: Serves as a precursor for creating novel chemical entities in drug discovery programs, especially for cancer and metabolic disease targets.
• Bioconjugation: Enables the site-specific attachment of drugs, probes, or other molecules to carriers like antibodies or polymers via its selectively deprotectable functional groups.
• Enzyme Substrate Analog: Used in biochemical assays to study the activity of glucuronidases and other carbohydrate-processing enzymes.
• Standards and Reference Material: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Methyl 2,3,4-Tri-o-Benzyl-β-D-Glucuronic Acid, Benzyl Ester
CAS No.	142797-33-9
Molecular Formula	C35H36O7
Molecular Weight	568.66 g/mol
Synonyms	Methyl 2,3,4-Tri-O-benzyl-β-D-glucopyranosiduronic Acid Benzyl Ester; 1-O-Methyl-2,3,4-tri-O-benzyl-β-D-glucuronic Acid Benzyl Ester; Benzyl (Methyl 2,3,4-Tri-O-benzyl-β-D-glucopyranosid)uronate; Methyl 2,3,4-Tri-O-benzyl-1-O-methyl-β-D-glucuronate Benzyl Ester; Protected Glucuronic Acid Benzyl Ester; Tri-O-benzyl Glucuronic Acid Methyl Ester Benzyl Ester
EINECS	Contact for details

Quality Control

Our Methyl 2,3,4-Tri-o-Benzyl-β-D-Glucuronic Acid, Benzyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and chiral analysis to ensure stereochemical integrity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting identity, purity, and impurity profiles to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-20° to -25° (c=1 in CHCl3)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.