Description

Cyclobutanecarboxylic Acid, 3-(Aminocarbonyl)-, Methyl Ester, cis- (9Ci) is a specialized, high-purity chemical building block featuring a constrained cyclobutane ring system. This compound is valued for its role as a key chiral intermediate in advanced pharmaceutical synthesis and fine chemical research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce unique steric and conformational properties into target molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex, constrained molecular architectures.
• Agrochemical Research: Serves as a building block for creating new generations of herbicides, fungicides, and insecticides with potentially improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Used in the synthesis of specialized ligands for asymmetric catalysis and organometallic complexes.
• Peptidomimetics and Bioisosteres: The cis-configured cyclobutane ring is employed to mimic peptide bonds or other structural motifs, enhancing metabolic stability and bioavailability in drug candidates.
• Material Science Precursor: Acts as a monomer or functionalizing agent in the synthesis of polymers and advanced materials with tailored physical properties.
• Academic and Contract Research: A valuable reagent for methodological studies in organic synthesis, including ring-opening and functionalization reactions.

Basic Information

Item	Detail
Product Name	Cyclobutanecarboxylic Acid, 3-(Aminocarbonyl)-, Methyl Ester, cis- (9Ci)
CAS No.	142733-62-8
Molecular Formula	C7H11NO3
Molecular Weight	157.17 g/mol
Synonyms	cis-3-Carbamoylcyclobutanecarboxylic acid methyl ester; Methyl cis-3-aminocarbonylcyclobutanecarboxylate; cis-Methyl 3-carbamoylcyclobutanecarboxylate; (1r,3s)-3-(Aminocarbonyl)cyclobutanecarboxylic Acid Methyl Ester; (1s,3r)-3-(Aminocarbonyl)cyclobutanecarboxylic Acid Methyl Ester; Cyclobutanecarboxylic acid, 3-(aminocarbonyl)-, methyl ester, cis-; cis-3-Carbamoylcyclobutane-1-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of Cyclobutanecarboxylic Acid, 3-(Aminocarbonyl)-, Methyl Ester, cis- (9Ci) is produced and tested under a strict quality management system. We provide comprehensive analytical data including HPLC purity, chiral purity, and identity confirmation to ensure the material meets your precise research or production requirements. A Certificate of Analysis (COA) detailing all specifications is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.