Description

cis-3-(Methoxycarbonyl)Cyclobutanecarboxylic Acid is a high-purity, functionalized cyclobutane derivative serving as a versatile chiral building block in advanced organic synthesis. Its rigid, strained four-membered ring structure and dual carboxylic acid/ester functionality make it a critical intermediate for constructing complex molecular architectures with precise stereochemistry. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for synthesizing novel active ingredients, chiral ligands, and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific stereochemistry for efficacy.
• Chiral Ligand & Catalyst Precursor: Serves as a starting material for synthesizing sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with unique thermal or mechanical properties derived from the cyclobutane core.
• Peptidomimetics & Bioisosteres: The constrained cyclobutane ring is utilized to replace more flexible moieties in peptide analogs, enhancing metabolic stability and binding affinity.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development, quality control, and regulatory submissions.

Basic Information

Item	Detail
Product Name	cis-3-(Methoxycarbonyl)Cyclobutanecarboxylic Acid
CAS No.	142733-61-7
Molecular Formula	C7H10O4
Molecular Weight	158.15 g/mol
Synonyms	cis-3-(Methoxycarbonyl)cyclobutanecarboxylic acid; (1r,3s)-3-(Methoxycarbonyl)cyclobutanecarboxylic acid; Methyl cis-3-carboxycyclobutanecarboxylate; cis-3-Carbomethoxycyclobutanecarboxylic acid; Cyclobutanecarboxylic acid, 3-(methoxycarbonyl)-, cis-; 3-(Methoxycarbonyl)cyclobutanecarboxylic acid (cis-); (1S,3R)-3-(Methoxycarbonyl)cyclobutanecarboxylic acid; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of cis-3-(Methoxycarbonyl)Cyclobutanecarboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting identity, purity (typically ≥97% by HPLC), chiral purity, and impurity profiles. Our quality protocols are designed to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.