Description

Cyclopropanecarboxylic Acid, 2-Cyano-1-Methyl-, Ethyl Ester, trans- (9Ci) is a high-purity, specialized organic ester building block with a constrained cyclopropane ring system. This compound matters for its role as a critical chiral intermediate in the synthesis of complex, biologically active molecules, offering unique steric and electronic properties. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapies.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the cyclopropane moiety can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and liquid crystals, leveraging its rigid molecular structure.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 2-Cyano-1-Methyl-, Ethyl Ester, trans- (9Ci)
CAS No.	142653-22-3
Molecular Formula	C8H11NO2
Molecular Weight	153.18 g/mol
Synonyms	trans-Ethyl 2-cyano-1-methylcyclopropanecarboxylate; Ethyl (1R,2S)-2-cyano-1-methylcyclopropanecarboxylate; Ethyl (1S,2R)-2-cyano-1-methylcyclopropanecarboxylate; trans-2-Cyano-1-methylcyclopropanecarboxylic acid ethyl ester; (1R,2S)-rel-2-Cyano-1-methylcyclopropanecarboxylic Acid Ethyl Ester; Ethyl trans-2-cyano-1-methylcyclopropane-1-carboxylate; 2-Cyano-1-methylcyclopropanecarboxylic acid ethyl ester, trans-
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxylic Acid, 2-Cyano-1-Methyl-, Ethyl Ester, trans- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container must be kept tightly closed in a dry and inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.