Description

(+)-Bis((R)-4,4-Dimethyl-2-Oxotetrahydro -3-Furyl))Fumarate CAS NO 142608-02-4 is a high-purity, chiral chemical intermediate characterized by its fumarate ester structure linked to two (R)-configured lactone units. This compound matters for its role as a critical building block in the synthesis of complex, biologically active molecules, offering precise stereochemical control. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in developing advanced therapeutics, including protease inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for antiviral and anticancer agents.
• Asymmetric Synthesis: Utilized as a precursor or auxiliary in stereoselective organic synthesis to construct complex molecular architectures with high enantiomeric purity.
• Protease Inhibitor Development: Serves as a core structural component in the synthesis of protease inhibitor candidates, leveraging its specific stereochemistry.
• Chemical Research: Employed in academic and industrial R&D for studying structure-activity relationships (SAR) and developing new synthetic methodologies.
• Fine Chemical Production: Used in the scaled-up manufacture of specialty fine chemicals where high chiral purity is a mandatory requirement.

Basic Information

Product Name	(+)-Bis((R)-4,4-Dimethyl-2-Oxotetrahydro-3-Furyl))Fumarate
CAS No.	142608-02-4
Molecular Formula	C18H24O8
Molecular Weight	368.38 g/mol
Synonyms	(+)-Bis[(R)-4,4-Dimethyl-2-oxotetrahydro-3-furanyl] Fumarate; (R,R)-Bis(4,4-dimethyl-2-oxotetrahydrofuran-3-yl) fumarate; Fumaric Acid Bis[(R)-4,4-Dimethyl-2-oxotetrahydro-3-furanyl] Ester; (3R,3'R)-Bis(4,4-dimethyl-2-oxotetrahydrofuran-3-yl) (E)-but-2-enedioate; (R)-4,4-Dimethyl-2-oxotetrahydro-3-furanyl fumarate dimer
EINECS	Contact for details

Quality Control

Our (+)-Bis((R)-4,4-Dimethyl-2-Oxotetrahydro-3-Furyl))Fumarate is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure compliance with high-purity standards for research and pharmaceutical applications. Certificates of Analysis (COA) documenting identity, purity, chiral purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.