Description

1 α-(Hydroxymethyl)-25-Hydroxyvitamin D3 is a synthetic, biologically active vitamin D3 analog, representing a significant advancement in the development of vitamin D receptor modulators. This compound is valued for its potent and selective activity, offering researchers and formulators a powerful tool for studying and influencing calcium metabolism and cellular differentiation. It is primarily utilized in the pharmaceutical and life science research sectors for developing novel therapeutic agents and conducting advanced biochemical studies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of next-generation vitamin D-based therapeutics targeting osteoporosis, psoriasis, and secondary hyperparathyroidism.
• Biochemical Research: Used as a reference standard and active compound in studies of vitamin D receptor (VDR) activation, gene expression, and cell signaling pathways.
• Metabolic Studies: Critical for investigating the role of vitamin D analogs in calcium and phosphate homeostasis in preclinical models.
• Drug Discovery & Development: Serves as a lead compound or precursor for creating new chemical entities with optimized pharmacokinetic and pharmacodynamic profiles.

Basic Information

Product Name	1 α-(Hydroxymethyl)-25-Hydroxyvitamin D3
CAS No.	142508-67-6
Molecular Formula	C₂₈H₄₄O₄
Molecular Weight	444.65 g/mol
Synonyms	1α-(Hydroxymethyl)-25-hydroxyvitamin D3; 1α-Hydroxymethyl-25-hydroxyvitamin D3; 1α-Hydroxymethyl-25-hydroxy-cholecalciferol; 1α-Hydroxymethyl-25-OH-D3; 1α-Hydroxymethyl-25-hydroxycholecalciferol; 1α-(Hydroxymethyl)-25-hydroxycholecalciferol; 1α-Hydroxymethyl-25-hydroxy vitamin D3
EINECS	Contact for details

Quality Control

Our 1 α-(Hydroxymethyl)-25-Hydroxyvitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to prevent oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.