Description

(S)-2-tert-Butoxycarbonylamino-3-[4-(Diethoxy-Phosphorylmethyl)-Phenyl]-Propionic Acid CAS NO 142348-55-8 is a high-purity, non-natural amino acid derivative featuring a phosphonate group, making it a critical building block for advanced pharmaceutical research and development. This compound is essential for the synthesis of peptide-based drugs and enzyme inhibitors, where its chiral purity and functional groups enable precise molecular targeting. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, kinase inhibitors, and other targeted therapeutics.
• Peptidomimetic Drug Design: Serves as a phosphonate-containing amino acid analog for constructing stable peptide mimics with enhanced bioavailability and metabolic stability.
• Chemical Biology Probes: Used in the development of activity-based probes and inhibitors for studying enzyme mechanisms and signal transduction pathways.
• Agrochemical Research: Employed as a building block for novel herbicides and plant growth regulators that mimic amino acid structures.
• Material Science: Potential monomer for creating functionalized polymers with specific ligand-binding capabilities.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and niche fine chemicals.

Basic Information

Product Name	(S)-2-tert-Butoxycarbonylamino-3-[4-(Diethoxy-Phosphorylmethyl)-Phenyl]-Propionic Acid
CAS No.	142348-55-8
Molecular Formula	C19H30NO7P
Molecular Weight	415.42 g/mol
Synonyms	Boc-Phe(4-CH2PO(OEt)2)-OH; (S)-2-((tert-Butoxycarbonyl)amino)-3-(4-((diethoxyphosphoryl)methyl)phenyl)propanoic acid; N-Boc-O-diethylphosphonomethyl-L-tyrosine; N-Boc-L-Tyr(PO(OEt)2); Fmoc-Phe(4-CH2PO(OEt)2)-OH (related protected form); 4-[(Diethoxyphosphoryl)methyl]-L-phenylalanine, N-Boc-; Boc-L-4-(Diethoxyphosphonomethyl)phenylalanine
EINECS	Contact for details

Quality Control

Our production of (S)-2-tert-Butoxycarbonylamino-3-[4-(Diethoxy-Phosphorylmethyl)-Phenyl]-Propionic Acid adheres to stringent quality management systems. Every batch is subjected to comprehensive analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with research and development-grade specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to guarantee traceability and consistency for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.