Description

n-(Alpha)-(N,n-Dimethylcarbamoyl)-α-Azaornithine 4-Nitrophenyl Ester CAS NO 142181-98-4 is a specialized, high-purity chemical building block designed for advanced organic synthesis and pharmaceutical research. This compound is valued for its role as a reactive ester intermediate, facilitating the controlled introduction of specific functional groups into complex molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the development of novel active ingredients and biochemical probes.

Application

This advanced synthetic intermediate is engineered for precision applications in research and development. Key uses include:

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly those targeting enzymatic pathways.
• Protease Inhibitor Research: Used in the development and study of protease inhibitors due to its structural similarity to transition-state analogs.
• Peptidomimetic Synthesis: Acts as a crucial component for constructing modified peptide backbones (aza-peptides) with enhanced stability or biological activity.
• Bioconjugation: Employed in labeling and cross-linking strategies for proteins and other biomolecules, leveraging the reactivity of the 4-nitrophenyl ester group.
• Chemical Biology Probe Development: Utilized to create activity-based probes for studying enzyme function and mechanism in complex biological systems.
• Agrochemical Research: Applied in the synthesis of new active ingredients for crop protection products.

Basic Information

Product Name	n-(Alpha)-(N,n-Dimethylcarbamoyl)-α-Azaornithine 4-Nitrophenyl Ester
CAS No.	142181-98-4
Molecular Formula	C14H19N5O5
Molecular Weight	337.33 g/mol
Synonyms	Nα-(N,N-Dimethylcarbamoyl)-α-azaornithine 4-nitrophenyl ester; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidinopentanoic acid; Azaornithine(4-NO2-Ph) derivative; Fmoc-AzaOrn(4-NO2-Ph)-OH (common abbreviation); Protease inhibitor intermediate PNPO ester; N-[(Dimethylamino)carbonyl]-L-2,4-diaminobutanoic acid 4-nitrophenyl ester
EINECS	Contact for details

Quality Control

Our production of n-(Alpha)-(N,n-Dimethylcarbamoyl)-α-Azaornithine 4-Nitrophenyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with cGMP and ISO 9001 standards for research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C under an inert atmosphere. This compound is moisture-sensitive (hygroscopic) and should be handled in a dry environment. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.