Description

Methyl (2S)-2-{[(Benzyloxy)Carbonyl]Amino}-5-(1,3-Dioxoisoindol-2-Yl)Pentanoate CAS NO 142165-70-6 is a high-purity, protected amino acid derivative designed for advanced organic synthesis. This compound serves as a critical chiral building block, enabling the precise construction of complex peptide and peptidomimetic structures. It is essential for researchers and manufacturers in pharmaceutical development, particularly in the synthesis of active pharmaceutical ingredients (APIs) and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of peptide-based drugs and bioactive molecules.
• Peptide Chemistry: Used for the controlled introduction of specific amino acid residues with orthogonal protecting groups (Cbz and Phth) in solid-phase and solution-phase peptide synthesis.
• Protease Inhibitor Research: Serves as a core structure or precursor in the development of enzyme inhibitors targeting various proteases.
• Chemical Biology & Drug Discovery: Employed in the design and synthesis of chemical probes, labeled peptides, and libraries for high-throughput screening.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic synthesis and medicinal chemistry research.

Basic Information

Product Name	Methyl (2S)-2-{[(Benzyloxy)Carbonyl]Amino}-5-(1,3-Dioxoisoindol-2-Yl)Pentanoate
CAS No.	142165-70-6
Molecular Formula	C23H22N2O6
Molecular Weight	422.43 g/mol
Synonyms	Methyl N2-(benzyloxycarbonyl)-N5-(phthaloyl)-L-ornithinate; Methyl Nα-Cbz-Nδ-Phth-L-ornithinate; Cbz-Orn(Phth)-OMe; Nα-Carbobenzoxy-Nδ-phthaloyl-L-ornithine methyl ester; (2S)-2-{[(Benzyloxy)carbonyl]amino}-5-(1,3-dioxoisoindol-2-yl)pentanoic acid methyl ester; L-Ornithine, N2-[(phenylmethoxy)carbonyl]-N5-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, methyl ester; Z-Orn(Phth)-OMe
EINECS	Contact for details

Quality Control

Our Methyl (2S)-2-{[(Benzyloxy)Carbonyl]Amino}-5-(1,3-Dioxoisoindol-2-Yl)Pentanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with exacting standards for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.