Description

1,6-Di-o-Acetyl-2,3-Isopropylidene-D-Ribose is a key protected ribose derivative, serving as a crucial chiral building block and synthetic intermediate in advanced organic synthesis. Its value lies in providing a chemically stable and reactive scaffold for the controlled construction of complex nucleoside analogs and other biologically active molecules. This high-purity intermediate is essential for pharmaceutical R&D and production, particularly in the synthesis of antiviral and anticancer agents, as well as for specialized fine chemical manufacturing.

Application

• Nucleoside & Nucleotide Synthesis: A critical protected intermediate for the preparation of modified ribonucleosides and their analogs.
• Antiviral Drug Development: Used in the research and production of active pharmaceutical ingredients (APIs) targeting viral diseases.
• Anticancer Agent Research: Serves as a building block for novel chemotherapeutic compounds and prodrugs.
• Carbohydrate Chemistry: A versatile starting material for the synthesis of complex sugars, glycoconjugates, and glycomimetics.
• Fine Chemical Intermediate: Employed in custom synthesis and contract manufacturing for high-value specialty chemicals.
• Bioconjugation & Probe Development: Useful for creating labeled nucleotides or carbohydrate-based probes for diagnostic and research applications.

Basic Information

Product Name	1,6-Di-o-Acetyl-2,3-Isopropylidene-D-Ribose
CAS No.	141979-56-8
Molecular Formula	C₁₂H₁₈O₇
Molecular Weight	274.27 g/mol
Synonyms	1,6-Di-O-acetyl-2,3-O-isopropylidene-D-ribofuranose; D-Ribose, 1,6-di-O-acetyl-2,3-O-isopropylidene-; 2,3-O-Isopropylidene-1,6-di-O-acetyl-D-ribofuranose; 1,6-Di-O-acetyl-2,3-O-(1-methylethylidene)-D-ribofuranose; Protected D-Ribose Derivative; Acetylated Isopropylidene Ribose
EINECS	Contact for details

Quality Control

Our 1,6-Di-o-Acetyl-2,3-Isopropylidene-D-Ribose is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant ICH guidelines and can supply material that meets custom specifications for advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider using a desiccator or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.