Description

Ethyl (R)-(-)-4-Cyano-3-Hydroxybutyrate is a high-value chiral intermediate of significant importance in the synthesis of optically active pharmaceutical compounds. Its core value lies in its stereochemical purity, which is critical for producing enantiomerically pure active pharmaceutical ingredients (APIs) with the desired therapeutic efficacy and safety profile. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in developing and producing statin drugs and other chiral therapeutics.

Application

• Key Chiral Intermediate for Statin Synthesis: Serves as a critical building block in the multi-step synthesis of enantiomerically pure Atorvastatin, Rosuvastatin, and other HMG-CoA reductase inhibitors.
• Pharmaceutical Intermediate: Used in the research and commercial production of various other chiral drugs where the (R)-configured 3-hydroxy moiety is required for biological activity.
• Asymmetric Synthesis: Employed as a starting material or intermediate in sophisticated asymmetric synthesis routes to construct complex molecular architectures.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals, advanced materials, and ligands for catalysis that require high enantiomeric purity.
• Biocatalysis & Enzymatic Resolution Studies: Acts as a substrate or model compound in research focused on developing and optimizing enzymatic processes for chiral resolution.

Basic Information

Product Name	Ethyl (R)-(-)-4-Cyano-3-Hydroxybutyrate
CAS No.	141942-85-0
Molecular Formula	C7H11NO3
Molecular Weight	157.17 g/mol
Synonyms	(R)-Ethyl 4-Cyano-3-hydroxybutyrate; (R)-(-)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester; Ethyl (R)-3-Hydroxy-4-cyanobutanoate; (R)-3-Hydroxy-4-cyanobutanoic Acid Ethyl Ester; (R)-HCA-EE; (R)-Ethyl 3-Hydroxy-4-cyanobutyrate; Atorvastatin Intermediate; Chiral Hydroxy Nitrile Ester
EINECS	Contact for details

Quality Control

Our Ethyl (R)-(-)-4-Cyano-3-Hydroxybutyrate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity, which is paramount for pharmaceutical applications. Quality is verified through comprehensive analytical testing including chiral HPLC, NMR, and IR spectroscopy. A Certificate of Analysis (COA) detailing purity, enantiomeric excess (ee), and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.