Description

n-Succinimidyl-4-Fluorobenzoate is a high-purity, activated ester reagent specifically designed for bioconjugation and crosslinking applications. Its core value lies in its ability to efficiently introduce the 4-fluorobenzoyl moiety into target molecules, facilitating the creation of stable amide bonds under mild conditions. This compound is essential for researchers and manufacturers in the fields of biopharmaceutical development, proteomics, and diagnostic assay formulation, where precise and reliable protein modification is critical.

Application

• Bioconjugation Reagent: Primary use for labeling antibodies, proteins, and peptides with fluorophores, drugs, or other functional groups via amine-reactive chemistry.
• Proteomics Research: Employed in the synthesis of activity-based probes (ABPs) and affinity tags for studying enzyme function and protein-protein interactions.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key linker intermediate for attaching cytotoxic payloads to monoclonal antibodies in cancer therapeutics.
• Diagnostic Reagent Synthesis: Used to prepare enzyme conjugates and other labeled reagents for immunoassays (ELISA, lateral flow tests).
• Surface Functionalization: Modifies surfaces of nanoparticles, biosensors, and microarrays to create amine-reactive sites for biomolecule immobilization.
• Polymer Chemistry: Acts as a functional monomer or crosslinker in the synthesis of specialty polymers with tailored biological activity.

Basic Information

Product Name	n-Succinimidyl-4-Fluorobenzoate
CAS No.	141762-27-8
Molecular Formula	C11H8FNO4
Molecular Weight	237.18 g/mol
Synonyms	4-Fluorobenzoic Acid N-Hydroxysuccinimide Ester; 4-Fluoro-N-succinimidylbenzoate; N-Succinimidyl 4-Fluorobenzoate; NHS-Fluorobenzoate; 4-Fluorobenzoyloxy succinimide; Succinimidyl 4-fluorobenzoate; 141762-27-8; N-(4-Fluorobenzoyloxy)succinimide
EINECS	Contact for details

Quality Control

Our n-Succinimidyl-4-Fluorobenzoate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere (argon or nitrogen) after each use to maintain stability and prevent hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.