Description

4-(Trifluoromethyl)Umbelliferyl Acetate is a specialized fluorinated derivative of umbelliferone, a key coumarin scaffold. This compound is valued for its role as a critical intermediate and a fluorogenic substrate in the development of sensitive biochemical assays and diagnostic reagents. It is primarily sought by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic industries for applications in enzyme activity detection and high-throughput screening.

Application

• Fluorogenic Substrate for Enzymes: Used as a sensitive probe for detecting the activity of esterases, lipases, and other hydrolytic enzymes, where cleavage releases the highly fluorescent umbelliferone derivative.
• Biochemical Research & Assay Development: Serves as a key intermediate in synthesizing advanced probes for studying cellular processes and signal transduction pathways.
• Diagnostic Reagent Manufacturing: Incorporated into kits for clinical diagnostics and point-of-care testing devices to measure specific enzyme markers.
• High-Throughput Screening (HTS): Utilized in drug discovery platforms to identify potential inhibitors or activators of target enzymes in pharmaceutical R&D.
• Chemical Biology Tool: Acts as a building block for creating activity-based probes to profile enzyme function in complex biological samples.

Basic Information

Product Name	4-(Trifluoromethyl)Umbelliferyl Acetate
CAS No.	141573-62-8
Molecular Formula	C₁₂H₇F₃O₄
Molecular Weight	272.18 g/mol
Synonyms	4-(Trifluoromethyl)-7-acetoxycoumarin; 7-Acetoxy-4-(trifluoromethyl)coumarin; 4-Trifluoromethylumbelliferyl acetate; 4-TFMU acetate; 4-Trifluoromethyl-7-hydroxycoumarin acetate; 4-Methylumbelliferyl acetate trifluoromethyl analog; 4-CF3-7-Acetoxycoumarin; 7-Acetoxy-4-trifluoromethyl-2H-chromen-2-one
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Umbelliferyl Acetate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and diagnostic applications. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.