Description

Boc-D-Ser-Obzl is a protected amino acid derivative, specifically the benzyl ester of D-serine with a tert-butoxycarbonyl (Boc) protecting group on the amine. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise control over stereochemistry and functional group reactivity. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the development of therapeutic peptides, protease inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediates: Key chiral synthon for the solid-phase and solution-phase synthesis of therapeutic peptides and peptidomimetic drugs.
• Protease Inhibitor Development: Used in the research and production of inhibitors targeting specific enzymes like serine proteases.
• Bioconjugation & Labeling: Serves as a precursor for introducing serine-based linkers or tags into biomolecules for diagnostic or research purposes.
• Chemical Biology Research: Employed in the study of protein-protein interactions and signal transduction pathways using synthetic peptide probes.
• Asymmetric Synthesis: Acts as a starting material or auxiliary in the asymmetric synthesis of non-proteinogenic amino acids and other chiral compounds.
• GPCR Ligand Synthesis: Used in the preparation of peptide-based ligands for G-protein-coupled receptors (GPCRs) in drug discovery.

Basic Information

Product Name	Boc-D-Ser-Obzl
CAS No.	141527-78-8
Molecular Formula	C15H21NO5
Molecular Weight	295.33 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-D-serine benzyl ester; Boc-D-serine benzyl ester; D-Serine, N-[(1,1-dimethylethoxy)carbonyl]-, phenylmethyl ester; (R)-2-((tert-Butoxycarbonyl)amino)-3-hydroxypropanoic acid benzyl ester; Boc-D-Ser-OBzl; Boc-D-Ser(Bzl)-OH (common abbreviation); Benzyl (R)-2-((tert-butoxycarbonyl)amino)-3-hydroxypropanoate
EINECS	Contact for details

Quality Control

Our Boc-D-Ser-Obzl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP intermediate applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant ICH guidelines for stability and impurity characterization to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent hydrolysis of the ester and protecting groups. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Melting Point	Contact for details
Specific Rotation	Contact for details
Heavy Metals	<10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.