Description

trans--Ethyl 3-(Benzyloxy)Cyclobutanecarboxylate is a high-purity organic building block and chiral intermediate of significant interest in advanced synthetic chemistry. This compound is valued for its rigid cyclobutane core and protected functional groups, which enable precise stereochemical control in complex molecular assembly. It is primarily utilized by research institutions and pharmaceutical development teams engaged in the synthesis of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for constructing complex, stereodefined molecular architectures.
• Agrochemical Synthesis: Used in the preparation of advanced crop protection agents and herbicides where specific stereochemistry is crucial for bioactivity.
• Organic Synthesis Building Block: Serves as a versatile precursor for further functionalization, including ring-opening, cross-coupling, and deprotection reactions in academic and industrial R&D.
• Material Science Research: Investigated for the development of novel polymers or liquid crystals that leverage the conformational constraints of the cyclobutane ring.
• Catalyst and Ligand Development: Employed as a starting material for synthesizing novel chiral ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	trans--Ethyl 3-(Benzyloxy)Cyclobutanecarboxylate
CAS No.	141352-63-8
Molecular Formula	C14H18O3
Molecular Weight	234.29 g/mol
Synonyms	Ethyl (1r,3r)-3-(Benzyloxy)cyclobutanecarboxylate; trans-3-(Benzyloxy)cyclobutanecarboxylic Acid Ethyl Ester; (1R,3R)-3-(Benzyloxy)cyclobutanecarboxylic Acid Ethyl Ester; 3-Benzyloxycyclobutanecarboxylic Acid Ethyl Ester (trans-); Ethyl trans-3-(Benzyloxy)cyclobutanecarboxylate; Cyclobutanecarboxylic acid, 3-(phenylmethoxy)-, ethyl ester, trans-; 141352-63-8; Benzyloxy Cyclobutane Ethyl Ester
EINECS	Contact for details

Quality Control

Our trans--Ethyl 3-(Benzyloxy)Cyclobutanecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat sources and incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Chiral Purity (Chiral HPLC)	≥ 98.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.