Description

2-Cyclobutene-1-Carboxylic Acid, 1-Formyl-, Methyl Ester (9Ci) is a specialized organic building block featuring a reactive cyclobutene core functionalized with both formyl and ester groups. This compound matters as a versatile synthon for constructing complex molecular architectures in advanced pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists working on novel active ingredients, particularly in medicinal chemistry for lead optimization and scaffold diversification. The unique strained-ring system offers distinct reactivity profiles for cycloaddition and functionalization reactions.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-inflammatory pathways.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides, leveraging its reactive structure to create novel bioactive molecules.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialty polymers with unique thermal or mechanical properties.
• Organic Synthesis Building Block: Employed in Diels-Alder and other cycloaddition reactions to construct complex, polycyclic frameworks in natural product synthesis.
• Chemical Biology Probe Development: Utilized to create labeled compounds or activity-based probes for studying enzyme mechanisms and protein interactions.

Basic Information

Product Name	2-Cyclobutene-1-Carboxylic Acid, 1-Formyl-, Methyl Ester (9Ci)
CAS No.	141232-84-0
Molecular Formula	C7H8O3
Molecular Weight	140.14 g/mol
Synonyms	Methyl 1-formyl-2-cyclobutene-1-carboxylate; 1-Formyl-2-cyclobutene-1-carboxylic acid methyl ester; Methyl 1-formylcyclobut-2-ene-1-carboxylate; 2-Cyclobutene-1-carboxylic acid, 1-formyl-, methyl ester; Cyclobut-2-ene-1-carboxylic acid, 1-formyl-, methyl ester
EINECS	Contact for details

Quality Control

Our 2-Cyclobutene-1-Carboxylic Acid, 1-Formyl-, Methyl Ester (9Ci) is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including chromatographic purity assessment and structural confirmation, to ensure consistency and reliability for your synthetic applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request, providing full traceability and compliance with internal and industry specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is sensitive to strong bases and should be kept away from such materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.