Description

Methyl 3-Iodobicyclo[1.1.1]Pentane-1-Carboxylate is a high-value, functionalized bicyclic building block designed for advanced organic synthesis. Its unique [1.1.1]propellane-derived, strained cage structure and reactive iodine handle make it a critical intermediate for constructing complex three-dimensional molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries seeking to develop novel bioactive compounds and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for creating sp3-rich, three-dimensional scaffolds that can improve drug-like properties.
• Agrochemical Research: Used to develop new active ingredients with unique modes of action by incorporating the rigid bicyclopentane core.
• Materials Science: Serves as a building block for advanced polymers, liquid crystals, and organic electronic materials requiring precise spatial control.
• Cross-Coupling Reactions: The iodine substituent enables efficient palladium-catalyzed cross-coupling (e.g., Suzuki, Stille, Negishi) for carbon-carbon bond formation.
• Bioisostere Development: The bicyclo[1.1.1]pentane unit is a valuable, non-classical bioisostere for a tert-butyl group or a phenyl ring, used to modulate potency, solubility, and metabolic stability.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tools for studying biological systems and target engagement.

Basic Information

Product Name	Methyl 3-Iodobicyclo[1.1.1]Pentane-1-Carboxylate
CAS No.	141046-59-5
Molecular Formula	C8H9IO2
Molecular Weight	264.06 g/mol
Synonyms	Methyl 3-iodobicyclo[1.1.1]pentane-1-carboxylate; 3-Iodobicyclo[1.1.1]pentane-1-carboxylic acid methyl ester; Methyl 3-iodo-1-bicyclo[1.1.1]pentanecarboxylate; 1-Carbomethoxy-3-iodobicyclo[1.1.1]pentane; Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-iodo-, methyl ester; 3-Iodo-BCP-methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 3-Iodobicyclo[1.1.1]Pentane-1-Carboxylate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.