Description

Bicyclo[2.1.1]Hexane-1-Carboxylic Acid, Methyl Ester (9Ci) is a high-value, strained bicyclic building block essential for advanced organic synthesis and pharmaceutical research. Its unique, rigid molecular framework makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and functional materials. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and cardiovascular diseases.
• Agrochemical Research: Used as a building block for developing new generation pesticides and herbicides with unique modes of action.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts due to its sterically defined, three-dimensional structure.
• Material Science: Employed in the synthesis of specialty polymers and advanced organic materials requiring rigid, bicyclic components.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic synthesis, including cycloaddition reactions and strain-release chemistry.
• Peptidomimetics: Used to incorporate constrained, non-natural amino acid analogs into peptide chains to modulate biological activity and stability.

Basic Information

Product Name	Bicyclo[2.1.1]Hexane-1-Carboxylic Acid, Methyl Ester (9Ci)
CAS No.	141046-53-9
Molecular Formula	C8H12O2
Molecular Weight	140.18 g/mol
Synonyms	Methyl bicyclo[2.1.1]hexane-1-carboxylate; 1-Bicyclo[2.1.1]hexanecarboxylic acid methyl ester; Methyl 1-bicyclo[2.1.1]hexanecarboxylate; Bicyclo[2.1.1]hexane-1-carboxylic acid methyl ester; 141046-53-9; Methyl bicyclo[2.1.1]hexyl-1-carboxylate
EINECS	Contact for details

Quality Control

Our Bicyclo[2.1.1]Hexane-1-Carboxylic Acid, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency essential for sensitive R&D and scale-up processes. Certificates of Analysis (COA) with full analytical data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0% (Standard Grade)
Purity (GC/HPLC)	≥ 98.0% (High Purity Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.