Description

(R)-1-Boc-3-(Hydroxymethyl)Piperidine CAS NO 140695-85-8 is a high-value, chiral piperidine derivative serving as a critical building block in modern organic synthesis. This compound matters because its protected amine and hydroxymethyl functionalities make it an indispensable intermediate for constructing complex, biologically active molecules with precise stereochemistry. Pharmaceutical researchers and fine chemical manufacturers need it for the development of new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated chiral scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel APIs, including potential candidates for central nervous system (CNS) disorders, oncology, and antiviral therapies.
• Peptidomimetic Chemistry: Used to introduce constrained, chiral piperidine motifs into peptide backbones to enhance metabolic stability and receptor selectivity.
• Ligand and Catalyst Synthesis: Employed in the preparation of chiral ligands for asymmetric catalysis and organocatalysts.
• Chemical Biology Probes: Serves as a scaffold for developing molecular probes to study enzyme function and biological pathways.
• Agrochemical Research: Utilized in the synthesis of advanced, chiral active ingredients for crop protection.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring high-purity, enantiomerically pure intermediates.

Basic Information

Product Name	(R)-1-Boc-3-(Hydroxymethyl)Piperidine
CAS No.	140695-85-8
Molecular Formula	C11H21NO3
Molecular Weight	215.29 g/mol
Synonyms	(R)-3-(Hydroxymethyl)-1-(tert-butoxycarbonyl)piperidine; (R)-1-(tert-Butoxycarbonyl)-3-piperidinemethanol; (R)-N-Boc-3-piperidinemethanol; (R)-1-Boc-3-piperidinemethanol; (R)-tert-Butyl 3-(hydroxymethyl)piperidine-1-carboxylate; (R)-1-N-Boc-3-(hydroxymethyl)piperidine; (3R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]piperidine-3-carbinol
EINECS	Contact for details

Quality Control

Our (R)-1-Boc-3-(Hydroxymethyl)Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial identification methods, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, chiral assay, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.