Description

Ethyl 2-Chloro-5-Fluoronicotinate is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its role as a versatile intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for research chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and other fine chemicals where the introduction of a halogenated nicotinate moiety is required.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, leveraging the fluorinated pyridine structure for enhanced biological activity.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D focused on heterocyclic chemistry and fluorination methodologies.
• Material Science Precursor: Potential intermediate for the synthesis of functionalized ligands and organic electronic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	Ethyl 2-Chloro-5-Fluoronicotinate
CAS No.	139911-30-1
Molecular Formula	C8H7ClFNO2
Molecular Weight	203.60 g/mol
Synonyms	2-Chloro-5-fluoronicotinic acid ethyl ester; Ethyl 2-chloro-5-fluoropyridine-3-carboxylate; 5-Fluoro-2-chloronicotinic acid ethyl ester; 3-Pyridinecarboxylic acid, 2-chloro-5-fluoro-, ethyl ester; 139911-30-1; Ethyl 2-chloro-5-fluoronicotinate; 2-Chloro-5-fluoro-3-pyridinecarboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-Chloro-5-Fluoronicotinate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.