Description

(R)-2-(Chloromethyl)-1,4-Dioxaspiro[4.5]Decane is a high-value chiral building block and key synthetic intermediate in advanced organic chemistry. This compound matters for its role in constructing complex, stereochemically defined molecules, particularly in the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals. Pharmaceutical R&D laboratories, agrochemical manufacturers, and specialty chemical producers need it to develop new therapeutic agents, chiral catalysts, and high-performance materials where precise stereochemistry is critical for efficacy and function.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of complex drug molecules, particularly in central nervous system (CNS) agents and cardiovascular drugs.
• Agrochemical Synthesis: Used in the research and production of chiral pesticides and herbicides, where the specific (R)-enantiomer can provide enhanced biological activity.
• Catalyst & Ligand Preparation: Serves as a precursor for developing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & Industrial Research: A valuable tool in medicinal chemistry and process development for exploring new synthetic routes to chiral targets.
• Material Science: Potential intermediate for creating chiral polymers or advanced organic materials with specific optical properties.

Basic Information

Product Name	(R)-2-(Chloromethyl)-1,4-Dioxaspiro[4.5]Decane
CAS No.	139892-53-8
Molecular Formula	C9H15ClO2
Molecular Weight	190.67 g/mol
Synonyms	(R)-2-(Chloromethyl)-1,4-dioxaspiro[4.5]decane; (R)-2-Chloromethyl-1,4-dioxaspiro[4.5]decane; (R)-Spiro[1,3-dioxolane-2,1'-cyclohexane]-2-methanol, 2-(chloromethyl)-; (R)-1,4-Dioxaspiro[4.5]decane-2-methanol, 2-(chloromethyl)-; (R)-2-Chloromethyl-1,4-dioxaspiro[4.5]decane; (R)-Chloromethyl Dioxaspirodecane; (R)-CMDS; (R)-Enantiomer of 2-(Chloromethyl)-1,4-dioxaspiro[4.5]decane
EINECS	Contact for details

Quality Control

Our (R)-2-(Chloromethyl)-1,4-Dioxaspiro[4.5]Decane is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis (HPLC/GC), to ensure compliance with exacting standards for pharmaceutical and fine chemical applications. Certificates of Analysis (COA) detailing identity, purity (typically ≥98.0%), enantiomeric excess (typically ≥99.0% ee), and impurity profiles are available upon request, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber or otherwise opaque.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Specific Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.