Description

Spiro[Cyclopentane-1,2-[3]Oxabicyclo[3.1.0]Hexan]-4-One, 6,6-Dimethyl- (9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic and oxabicyclic molecular architecture. This compound matters as a sophisticated building block for the synthesis of novel active pharmaceutical ingredients (APIs), enabling the development of drugs with complex stereochemistry and targeted biological activity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry, process development, and the production of specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders or requiring specific three-dimensional molecular frameworks.
• Medicinal Chemistry Research: Serves as a key scaffold for constructing compound libraries in drug discovery programs, allowing for the exploration of structure-activity relationships (SAR).
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Fine Chemical Synthesis: Employed in the production of specialty chemicals, agrochemicals, and other high-value compounds where its spirocyclic core imparts desirable physical or biological properties.
• Academic Research: Utilized in university and institutional labs for studies in organic synthesis methodology, asymmetric catalysis, and the development of new heterocyclic compounds.

Basic Information

Product Name	Spiro[Cyclopentane-1,2-[3]Oxabicyclo[3.1.0]Hexan]-4-One, 6,6-Dimethyl- (9Ci)
CAS No.	139885-96-4
Molecular Formula	C10H14O2
Molecular Weight	166.22 g/mol
Synonyms	6,6-Dimethylspiro[cyclopentane-1,2'-[3]oxabicyclo[3.1.0]hexan]-4-one; Spiro[cyclopentane-1,2'-[3]oxabicyclo[3.1.0]hexan]-4-one, 6,6-dimethyl-; 139885-96-4; 6,6-Dimethyl-4-oxaspiro[2.4]heptan-5-one (related bicyclic representation); Dimethyl-oxaspiroheptanone; Advanced Spirocyclic Intermediate
EINECS	Contact for details

Quality Control

Our Spiro[Cyclopentane-1,2-[3]Oxabicyclo[3.1.0]Hexan]-4-One, 6,6-Dimethyl- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents are provided with every shipment. We support compliance with cGMP, ICH Q7, and other relevant regulatory guidelines for advanced synthetic intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.