Description

Fmoc-Leu-OMe is a protected amino acid derivative, specifically the methyl ester of Fmoc-Leucine. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptides. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key reagent for the automated, stepwise construction of custom peptides.
• Pharmaceutical Research: Synthesis of peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Bioconjugation: Used to introduce leucine residues into proteins, antibodies, or other biomolecules for labeling or functionalization.
• Combinatorial Chemistry: A fundamental component in libraries for high-throughput screening of bioactive compounds.
• Academic & Industrial R&D: For studying protein structure-function relationships, enzyme substrates, and inhibitors.
• Production of Specialty Peptides: Manufacture of peptides for cosmetic, nutraceutical, and diagnostic applications.

Basic Information

Product Name	Fmoc-Leu-OMe
CAS No.	139551-80-7
Molecular Formula	C22H25NO4
Molecular Weight	367.44 g/mol
Synonyms	Fmoc-L-leucine methyl ester; N-(9-Fluorenylmethoxycarbonyl)-L-leucine methyl ester; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-4-methylpentanoic acid methyl ester; Fmoc-Leucine-OMe; Fmoc-Leu-OCH3; FMOC-LEU-OME; FMOC-L-LEUCINE METHYL ESTER; Nα-Fmoc-L-leucine methyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Leu-OMe is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive applications like peptide synthesis. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality commitment aligns with the standards expected for fine chemical and pharmaceutical-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation from atmospheric moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.