Description

γ-Methyl-α-(Trifluoromethyl)-γ-Butyrolactone is a high-value, fluorinated lactone building block. This compound is prized for its unique structural motif, which combines a reactive lactone ring with a trifluoromethyl group, offering significant potential for modifying molecular properties. It serves as a critical intermediate for researchers and manufacturers in advanced organic synthesis, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. Its application is essential for introducing fluorinated segments to enhance metabolic stability, bioavailability, and lipophilicity in target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex fluorinated heterocycles and bioactive molecules in drug discovery and development.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental profile.
• Advanced Material Precursor: Serves as a monomer or building block for specialty polymers and liquid crystals with tailored optical or electronic properties.
• Organic Synthesis Reagent: Employed in asymmetric synthesis and ring-opening reactions to create chiral, fluorinated carboxylic acids and derivatives.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research focused on incorporating fluorine atoms into complex molecular architectures.

Basic Information

Product Name	γ-Methyl-α-(Trifluoromethyl)-γ-Butyrolactone
CAS No.	139547-12-9
Molecular Formula	C7H7F3O2
Molecular Weight	180.12 g/mol
Synonyms	3-Methyl-4-(trifluoromethyl)dihydrofuran-2(3H)-one; 4-(Trifluoromethyl)-3-methylbutyrolactone; α-(Trifluoromethyl)-γ-methyl-γ-butyrolactone; 3-Methyl-4-trifluoromethyl-2-butyrolactone; γ-Methyl-α-(trifluoromethyl)butyrolactone; 4,4,4-Trifluoro-3-methylbutyrolactone
EINECS	Contact for details

Quality Control

Our γ-Methyl-α-(Trifluoromethyl)-γ-Butyrolactone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (HPLC, GC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.