Description

8-(Benzyloxycarbonyl)-1,4-Dioxa-8-Azaspiro[4.5]Decane is a protected amino acid derivative and a key spirocyclic building block in advanced organic synthesis. This compound is valued for its role as a versatile intermediate in the construction of complex nitrogen-containing heterocycles and active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel compounds and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of spirocyclic and bridged nitrogen heterocycles, which are core structures in many drug candidates targeting neurological and metabolic disorders.
• Peptidomimetics Research: Used in the design and synthesis of peptidomimetics and constrained peptides to improve metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides and insecticides with spirocyclic architectures.
• Chemical Biology Probes: Employed in the creation of specialized molecular probes and inhibitors for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A high-value starting material for custom synthesis projects and contract research organizations (CROs/CMOs) requiring specific chiral or protected intermediates.
• Academic & Process Chemistry: Utilized in academic research for methodology development and in process chemistry for scaling up synthetic routes to target molecules.

Basic Information

Product Name	8-(Benzyloxycarbonyl)-1,4-Dioxa-8-Azaspiro[4.5]Decane
CAS No.	139524-58-6
Molecular Formula	C15H19NO4
Molecular Weight	277.32 g/mol
Synonyms	1,4-Dioxa-8-azaspiro[4.5]decane-8-carboxylic acid benzyl ester; 8-Cbz-1,4-dioxa-8-azaspiro[4.5]decane; Cbz-1,4-dioxa-8-azaspiro[4.5]decane; 8-(Benzyloxycarbonyl)-1,4-dioxa-8-azaspiro[4.5]decane; 8-N-Cbz-1,4-dioxa-8-azaspiro[4.5]decane; 8-[(Benzyloxy)carbonyl]-1,4-dioxa-8-azaspiro[4.5]decane; 1,4-Dioxa-8-azaspiro[4.5]decane-8-carboxylic acid, benzyl ester; Z-1,4-Dioxa-8-azaspiro[4.5]decane
EINECS	Contact for details

Quality Control

Our 8-(Benzyloxycarbonyl)-1,4-Dioxa-8-Azaspiro[4.5]Decane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.