Description

2-(3-(4-(2-Quinolyl))-1-Piperazinyl)Propyl-1,2,4-Triazolo(4,3-A)Pyridin-3(2H)-One is a high-purity, complex heterocyclic compound that serves as a critical advanced pharmaceutical intermediate. Its molecular architecture, featuring fused triazolopyridine and quinoline moieties linked by a piperazinylpropyl chain, makes it a valuable building block for targeted drug discovery and development. This compound is essential for research and manufacturing in the pharmaceutical industry, particularly for synthesizing novel therapeutic agents with potential central nervous system or oncological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and psychiatric drug candidates.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities targeting specific receptors.
• Preclinical Development: Serves as a critical material for pharmacokinetic, pharmacodynamic, and toxicology studies during the drug development pipeline.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-compliant production of clinical trial materials and commercial APIs.
• Academic & Institutional Research: Utilized in university and institutional labs for fundamental research in organic synthesis and pharmacology.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method validation in analytical laboratories.

Basic Information

Item	Detail
Product Name	2-(3-(4-(2-Quinolyl))-1-Piperazinyl)Propyl-1,2,4-Triazolo(4,3-A)Pyridin-3(2H)-One
CAS No.	139477-46-6
Molecular Formula	C22H22N6O
Molecular Weight	386.45 g/mol
Synonyms	2-[3-[4-(2-Quinolyl)-1-piperazinyl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one; 2-(3-(4-(Quinolin-2-yl)piperazin-1-yl)propyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one; UNII-9QZ7H6F8C4; 139477-46-6; 9QZ7H6F8C4; ATC code N05AX; Triazolopyridine quinoline derivative
EINECS	Contact for details

Quality Control

Our 2-(3-(4-(2-Quinolyl))-1-Piperazinyl)Propyl-1,2,4-Triazolo(4,3-A)Pyridin-3(2H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing comprehensive HPLC purity, related substances, and residual solvents are provided with every shipment. We support compliance with cGMP, ICH Q7 guidelines, and REACH regulations for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.