Description

Methyl(2S)-1-(1',2'-Dioxo-2'-Methoxyethyl)-2-Pyrrolidine-Carboxylate is a high-purity chiral intermediate of significant importance in modern synthetic chemistry. Its value lies in its role as a key building block for the synthesis of complex, biologically active molecules, enabling precise stereochemical control. This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs), particularly in areas requiring sophisticated pyrrolidine-based scaffolds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of novel drug candidates, especially protease inhibitors and other enzyme-targeted therapies.
• Asymmetric Synthesis: Employed as a precursor or auxiliary in catalytic asymmetric reactions to construct stereogenic centers with high enantiomeric excess.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Peptidomimetic Development: Serves as a constrained proline analog for designing and synthesizing peptide mimics with enhanced metabolic stability and bioavailability.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis organizations (CSOs) producing advanced intermediates under cGMP for clinical trial materials.

Basic Information

Product Name	Methyl(2S)-1-(1',2'-Dioxo-2'-Methoxyethyl)-2-Pyrrolidine-Carboxylate
CAS No.	139419-63-9
Molecular Formula	C9H13NO5
Molecular Weight	215.20 g/mol
Synonyms	(S)-1-(2-Methoxy-2-oxoacetyl)-2-pyrrolidinecarboxylic acid methyl ester; (S)-Methyl 1-(2-methoxy-2-oxoacetyl)pyrrolidine-2-carboxylate; L-Proline, 1-(2-methoxy-2-oxoacetyl)-, methyl ester; Methyl (2S)-1-(2-methoxy-2-oxoacetyl)-2-pyrrolidinecarboxylate; Methyl (S)-1-(2-methoxy-2-oxoacetyl)pyrrolidine-2-carboxylate; (S)-1-(Methoxyoxalyl)-2-pyrrolidinecarboxylic acid methyl ester; (S)-Methyl 1-(methoxyoxalyl)pyrrolidine-2-carboxylate; Methyl (2S)-1-(1,2-dioxo-2-methoxyethyl)-2-pyrrolidinecarboxylate
EINECS	Contact for details

Quality Control

Our Methyl(2S)-1-(1',2'-Dioxo-2'-Methoxyethyl)-2-Pyrrolidine-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.