Description

(1α,3R,4α,5R)-3,5-Bis[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-1-Hydroxy-4-(1H-Imidazol-1-Ylthioxomethoxy)-Cyclohexanecarboxylic Acid Methyl Ester is a sophisticated, high-purity synthetic intermediate characterized by its protected hydroxyl groups and imidazole-derived functionalization. This compound matters as a critical building block in advanced organic synthesis, enabling the precise construction of complex molecular architectures. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, particularly those requiring stereochemical control.
• Organic Synthesis Research: Used in academic and industrial R&D for exploring new synthetic methodologies and constructing novel heterocyclic compounds.
• Protected Synthon: Serves as a protected form of a dihydroxy cyclohexane carboxylic acid derivative, allowing selective deprotection and further functionalization.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop new molecules with potential biological activity.
• Process Chemistry Development: Used for scaling up synthetic routes from laboratory to pilot plant scale under controlled conditions.
• Custom Synthesis: Supplied for contract manufacturing and custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Item	Details
Product Name	(1α,3R,4α,5R)-3,5-Bis[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-1-Hydroxy-4-(1H-Imidazol-1-Ylthioxomethoxy)-Cyclohexanecarboxylic Acid Methyl Ester
CAS No.	139356-32-4
Molecular Formula	C27H50N2O7SSi2
Molecular Weight	603.0 g/mol (approx.)
Synonyms	Methyl (1α,3R,4α,5R)-3,5-bis[(tert-butyldimethylsilyl)oxy]-1-hydroxy-4-[(1H-imidazol-1-yl)thioxomethoxy]cyclohexanecarboxylate; 1H-Imidazole-1-carbothioic acid O-[(1α,3R,4α,5R)-3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(methoxycarbonyl)cyclohex-4-yl] ester; TBDMS-protected imidazole carbothioate intermediate; Cyclohexanecarboxylic acid derivative, CAS 139356-32-4.
EINECS	Contact for details

Quality Control

Our (1α,3R,4α,5R)-3,5-Bis[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-1-Hydroxy-4-(1H-Imidazol-1-Ylthioxomethoxy)-Cyclohexanecarboxylic Acid Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing specific results for purity, related substances, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be sensitive to fluoride/strong alkali. Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.