Description

Nupafant CAS NO 139133-27-0 is a high-purity, small molecule pharmaceutical intermediate and research chemical. This compound is of significant commercial and scientific interest as a potent and selective platelet-activating factor (PAF) receptor antagonist. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the development of novel anti-inflammatory and anti-allergic therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced PAF antagonist drug candidates for clinical research.
• Biochemical Research: Used as a reference standard and active probe in pharmacological studies to investigate the role of PAF in inflammatory pathways.
• Mechanism of Action Studies: Essential tool compound for in vitro and ex vivo assays targeting PAF receptor-mediated signaling cascades.
• Preclinical Development: Serves as a critical material for formulation studies, pharmacokinetic profiling, and toxicology assessments during drug discovery.
• Reference Standard: Provides a certified benchmark for quality control and analytical method development in regulatory submissions.
• Academic Research: Supports university and institutional research into cardiovascular diseases, asthma, anaphylaxis, and other PAF-related disorders.

Basic Information

Product Name	Nupafant
CAS No.	139133-27-0
Molecular Formula	C₂₀H₂₀F₃N₃O₂
Molecular Weight	391.39 g/mol
Synonyms	Nupafant; 4-(2-Chlorophenyl)-9-methyl-2-[3-(4-morpholinyl)-3-oxopropyl]-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine; WEB 2347; 1,4-Diazepine, 4-(2-chlorophenyl)-9-methyl-2-[3-(4-morpholinyl)-3-oxopropyl]-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a]-; WEB-2347; CAS 139133-27-0
EINECS	Contact for details

Quality Control

Our Nupafant is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR, MS) and purity determination by validated chromatographic techniques (HPLC). A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound is light-sensitive (store away from light) and hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere when not in use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.