Description

4-Fluoro-3-(trifluoromethyl)phenyl isocyanate is a specialized aromatic isocyanate monomer featuring a unique combination of fluorine substituents. This compound is valued for its role as a key building block in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its structure imparts desirable properties like enhanced stability and lipophilicity. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty polymer industries for constructing ureas, carbamates, and other functional derivatives.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Specialty Polymer Production: Serves as a monomer for creating high-performance polyurethanes and polyurea coatings with enhanced chemical and thermal resistance.
• Liquid Crystal & OLED Materials: Incorporated into the molecular design of electronic display components to modify charge transport and alignment properties.
• Organic Synthesis Reagent: Employed in academic and industrial research labs for the introduction of the isocyanate functional group into complex molecular architectures.
• Cross-linking Agent: Functions as a reactive modifier in resins and adhesives to improve mechanical strength and durability.

Basic Information

Item	Details
Product Name	4-Fluoro-3-(trifluoromethyl)phenyl Isocyanate
CAS No.	139057-86-6
Molecular Formula	C8H3F4NO
Molecular Weight	205.11 g/mol
Synonyms	3-(Trifluoromethyl)-4-fluorophenyl isocyanate; 4-Fluoro-α,α,α-trifluoro-m-tolyl isocyanate; 1-Fluoro-2-isocyanato-5-(trifluoromethyl)benzene; Isocyanic acid, 4-fluoro-3-(trifluoromethyl)phenyl ester; 4-Fluoro-3-trifluoromethylphenyl isocyanate
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-3-(trifluoromethyl)phenyl isocyanate is produced and tested under strict quality management protocols. We ensure high purity and consistency through advanced analytical techniques including GC, HPLC, and NMR. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive (hygroscopic) and reactive nature. Keep away from heat, open flames, and sources of ignition. Isolate from moisture, alcohols, amines, and other nucleophiles.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.