Description

Pyridine, 4-[Fluoro(Trimethylsilyl)Methyl]- (9Ci) is a specialized organosilicon compound featuring a unique pyridine core functionalized with a fluoro(trimethylsilyl)methyl group. This structure makes it a valuable versatile building block and key intermediate in advanced synthetic chemistry, particularly for introducing fluorinated silicon-containing moieties. It is essential for R&D chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, especially those requiring fluorinated or silicon-based pharmacophores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorine and silicon groups can improve biological activity and environmental persistence.
• Material Science Research: Acts as a monomer or functionalization agent in the creation of specialty polymers, coatings, and silicon-based advanced materials.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic substitutions, and as a ligand precursor in organometallic chemistry due to its reactive pyridine and silyl groups.
• Fluorine Chemistry Reagent: Provides a source of a fluoromethylsilane unit for introducing fluorine atoms into complex molecular architectures under mild conditions.

Basic Information

Item	Detail
Product Name	Pyridine, 4-[Fluoro(Trimethylsilyl)Methyl]- (9Ci)
CAS No.	138761-49-6
Molecular Formula	C9H14FNSi
Molecular Weight	183.30 g/mol
Synonyms	4-[(Fluoro(trimethylsilyl)methyl]pyridine; 4-(Fluoro(trimethylsilyl)methyl)pyridine; (4-Pyridyl)(fluoro)trimethylsilane; α-Fluoro-4-pyridyltrimethylsilane; Trimethyl[4-pyridyl(fluoro)methyl]silane; 4-Pyridylfluoromethyltrimethylsilane; (Fluoro(4-pyridyl)methyl)trimethylsilane
EINECS	Contact for details

Quality Control

Our production of Pyridine, 4-[Fluoro(Trimethylsilyl)Methyl]- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and specific impurity profiles is provided with every shipment. We support cGMP and ISO compliant manufacturing for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.