Description

tert-Butyl3-(Hydroxymethyl)Bicyclo[1.1.1]Pentane-1-Carboxylate is a high-value, sterically hindered bicyclic building block of significant interest in advanced organic synthesis. Its unique [1.1.1]propellane-derived scaffold, featuring a rigid, three-dimensional structure with a hydroxymethyl handle, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in drug discovery, medicinal chemistry, and the development of novel materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for creating sp3-rich, three-dimensional fragments that can improve drug-like properties.
• Medicinal Chemistry & Drug Discovery: Used as a rigid, bioisosteric replacement for linear or planar aromatic systems to modulate solubility, metabolic stability, and target binding affinity in lead optimization.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and insecticides where its unique bicyclic structure can confer novel modes of action.
• Material Science Precursor: Acts as a monomer or cross-linking agent for synthesizing specialty polymers with tailored mechanical or thermal properties.
• Ligand and Catalyst Development: Utilized to construct sophisticated, sterically demanding ligands for asymmetric catalysis and organometallic chemistry.
• Chemical Biology Probes: Incorporated into molecular probes and tags to study biological systems due to its stability and potential for functionalization.

Basic Information

Product Name	tert-Butyl3-(Hydroxymethyl)Bicyclo[1.1.1]Pentane-1-Carboxylate
CAS No.	138732-32-8
Molecular Formula	C12H20O3
Molecular Weight	212.29 g/mol
Synonyms	3-(Hydroxymethyl)bicyclo[1.1.1]pentane-1-carboxylic acid tert-butyl ester; tert-Butyl 3-(hydroxymethyl)bicyclo[1.1.1]pentane-1-carboxylate; 1,3-Bicyclo[1.1.1]pentanediylbis(methanol), 1-tert-butoxycarbonyl derivative; Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester; [1.1.1]Propellane derivative; BCP-OH-tBu ester; tert-Butyl 3-(hydroxymethyl)-1-bicyclo[1.1.1]pentanecarboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl3-(Hydroxymethyl)Bicyclo[1.1.1]Pentane-1-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We employ advanced analytical techniques including HPLC, GC, and NMR to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.