Description

Eszopiclone is a non-benzodiazepine hypnotic agent belonging to the cyclopyrrolone class, primarily used for the treatment of insomnia. Its high selectivity for the GABA-A receptor complex ensures effective sleep induction and maintenance with a favorable safety profile. This active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers developing generic and branded sedative-hypnotic formulations. Global demand is driven by its established efficacy in managing sleep disorders.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription sleep aid medications.
• Generic Drug Formulation: Serves as the key component in generic versions of branded insomnia treatments.
• Clinical Research: Utilized as a reference standard in pharmacokinetic and pharmacodynamic studies.
• Drug Development: Employed in preclinical and clinical trials for new sedative-hypnotic drug candidates.
• Finished Dosage Forms: Incorporated into various oral solid dosage forms such as tablets and capsules.

Basic Information

Product Name	Eszopiclone
CAS No.	138729-47-2
Molecular Formula	C16H17ClN6O3
Molecular Weight	388.80 g/mol
Synonyms	(S)-Zopiclone; Estorra; Lunesta; (5S)-6-(5-Chloro-2-pyridinyl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methyl-1-piperazinecarboxylate; S-Zopiclone; Dexzopiclone; Esopiclone; (+)-Zopiclone
EINECS	Contact for details

Quality Control

Our Eszopiclone is manufactured under strict quality management systems, ensuring it meets the rigorous standards required for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profiling via HPLC and related substances methods. We provide full traceability and support regulatory submissions with detailed documentation. Certificates of Analysis (COA) confirming compliance with in-house specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The container should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	NMT 1.0%
Heavy Metals	NMT 20 ppm
Sulfated Ash	NMT 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.