Description

(R)-Zopiclone CAS NO 138680-08-7 is the single enantiomer of the non-benzodiazepine sedative-hypnotic agent Zopiclone. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the study of stereoselective pharmacology and the synthesis of novel therapeutic agents. It is primarily required by pharmaceutical R&D laboratories, analytical reference standard providers, and manufacturers of active pharmaceutical ingredients (APIs) for the development of advanced sleep disorder treatments.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control testing in regulatory submissions.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key chiral building block in the synthesis of enantiomerically pure sedative-hypnotic drugs.
• Pharmacological Research: Essential for preclinical and clinical studies investigating the stereospecific activity, metabolism, and toxicity profile of the (R)-enantiomer.
• Analytical Chemistry: Employed in chromatographic separations (HPLC, GC) as a standard to resolve and quantify enantiomeric mixtures.
• Process Development & Optimization: Used in scaling up asymmetric synthesis routes and developing robust manufacturing processes for chiral pharmaceuticals.

Basic Information

Product Name	(R)-Zopiclone
CAS No.	138680-08-7
Molecular Formula	C17H17ClN6O3
Molecular Weight	388.81 g/mol
Synonyms	(R)-Zopiclone; (6R)-6-(5-Chloro-2-pyridinyl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-Methyl-1-piperazinecarboxylate; Dexzopiclone; (R)-Enantiomer of Zopiclone; (R)-RP 62719; Eszopiclone Impurity; (R)-Lunesta Impurity; (6R)-6-(5-Chloropyridin-2-yl)-7-oxo-5,6-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate
EINECS	Contact for details

Quality Control

Our (R)-Zopiclone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical research and reference standard applications. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.