Description

1-(Tertbutoxycarbonyl)-1,2,3,6-Tetrahydropyridin-4-Yltrifluoromethanesulfonate is a high-purity, advanced pharmaceutical intermediate crucial for modern synthetic chemistry. This compound serves as a key building block for the introduction of a protected tetrahydropyridine moiety, enabling the synthesis of complex molecules with high regioselectivity. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, where the tetrahydropyridine scaffold is a valuable structural component.
• Cross-Coupling Reactions: Serves as an excellent electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) due to the reactive trifluoromethanesulfonate (triflate) group.
• Building Block for Heterocycles: Employed in the construction of more complex nitrogen-containing heterocyclic compounds, which are prevalent in bioactive molecules.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and kilogram-scale production under current Good Manufacturing Practice (cGMP) guidelines for clinical trial material.
• Academic & Contract Research: A valuable reagent for synthetic methodology development and exploration of new chemical spaces in academic and contract research organizations (CROs).

Basic Information

Product Name	1-(Tertbutoxycarbonyl)-1,2,3,6-Tetrahydropyridin-4-Yltrifluoromethanesulfonate
CAS No.	138647-49-1
Molecular Formula	C11H16F3NO5S
Molecular Weight	331.31 g/mol
Synonyms	1-Boc-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate; 1-Boc-4-triflyloxy-1,2,3,6-tetrahydropyridine; 4-[(Trifluoromethyl)sulfonyl]oxy-1-(1,1-dimethylethoxy)carbonyl]-1,2,3,6-tetrahydropyridine; 1,2,3,6-Tetrahydropyridin-4-ol, 1-[(1,1-dimethylethoxy)carbonyl]-, 4-(trifluoromethanesulfonate); N-Boc-4-triflyloxy-1,2,3,6-tetrahydropyridine; Boc-4-OTf-1,2,3,6-tetrahydropyridine; 1-(tert-Butoxycarbonyl)-4-(trifluoromethanesulfonyloxy)-1,2,3,6-tetrahydropyridine
EINECS	Contact for details

Quality Control

Our production of 1-(Tertbutoxycarbonyl)-1,2,3,6-Tetrahydropyridin-4-Yltrifluoromethanesulfonate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR, and other relevant tests. We support development and commercial projects with material produced under quality agreements, meeting the standards required for pharmaceutical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.