Description

(2R)-2-[[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]Methyl]-5-Oxo-1-Pyrrolidinecarboxylate-1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a protected pyrrolidinone core. This compound is critical for enabling complex synthetic routes in medicinal chemistry, particularly for the development of chiral active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel therapeutics, where its defined stereochemistry and protective groups offer precise control over molecular architecture.

Application

• Key Intermediate in API Synthesis: Serves as a crucial building block for the production of chiral pharmaceuticals, including protease inhibitors and other enzyme-targeted drugs.
• Asymmetric Synthesis: Employed in stereoselective reactions to construct complex molecules with high enantiomeric purity for preclinical and clinical research.
• Peptidomimetic Research: Used in the design and synthesis of peptidomimetics, which are important for developing drug candidates with improved metabolic stability.
• Process Chemistry Development: Integral to scaling up synthetic pathways from laboratory to pilot plant and commercial manufacturing scales.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity intermediates.
• Academic & Industrial R&D: A valuable reagent for chemists in both academic settings and industrial R&D departments exploring new chemical entities and synthetic methodologies.

Basic Information

Product Name	(2R)-2-[[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]Methyl]-5-Oxo-1-Pyrrolidinecarboxylate-1,1-Dimethylethyl Ester
CAS No.	138629-30-8
Molecular Formula	C27H37NO5Si
Molecular Weight	483.68 g/mol
Synonyms	tert-Butyl (2R)-2-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-oxopyrrolidine-1-carboxylate; (R)-1-Boc-2-((tert-butyldiphenylsilyloxy)methyl)-5-pyrrolidinone; (R)-1-(tert-Butoxycarbonyl)-2-((tert-butyldiphenylsilyloxy)methyl)-5-pyrrolidinone; (R)-N-Boc-2-((TBDPSO)methyl)-5-oxopyrrolidine; (2R)-1-(tert-Butoxycarbonyl)-2-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-pyrrolidinone; TBDPS-protected Boc-pyrrolidinone intermediate; (R)-Boc-Pro-OTBDPS lactam derivative
EINECS	Contact for details

Quality Control

Our (2R)-2-[[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]Methyl]-5-Oxo-1-Pyrrolidinecarboxylate-1,1-Dimethylethyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to meet the exacting standards required for pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is sensitive to fluoride and strong alkali; ensure it is stored separately from such materials to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.