Description

4-(tert-Butyldimethylsilyloxy)Benzyl Chloride is a versatile organosilicon-protected benzyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the dual functionality of the silyl ether protecting group and the reactive benzyl chloride moiety, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the synthesis of complex molecules, active pharmaceutical ingredients (APIs), and specialty intermediates where selective protection and functionalization are required.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs), leveraging the TBDMS-protected phenol for selective deprotection strategies.
• Peptide & Nucleoside Chemistry: Used as a reagent for introducing protecting groups or as a linker in solid-phase synthesis of peptides and modified nucleosides.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides, fungicides, and plant growth regulators requiring phenol-protected benzyl motifs.
• Material Science & Polymer Chemistry: Building block for creating functionalized monomers, dendrimers, and specialty polymers with tailored properties.
• Liquid Crystal & OLED Material Development: Serves as a synthetic intermediate for organic electronic materials where controlled substitution patterns are critical.
• Cross-Coupling Reactions: Useful substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing biaryl systems.
• Chiral Auxiliary & Catalyst Synthesis: Employed in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Research & Development: A valuable tool for academic and industrial R&D chemists exploring new synthetic methodologies and molecular architectures.

Basic Information

Product Name	4-(tert-Butyldimethylsilyloxy)Benzyl Chloride
CAS No.	138585-09-8
Molecular Formula	C13H21ClOSi
Molecular Weight	256.84 g/mol
Synonyms	4-[(tert-Butyldimethylsilyl)oxy]benzyl Chloride; 4-(TBDMSO)Benzyl Chloride; 1-Chloromethyl-4-[(tert-butyldimethylsilyl)oxy]benzene; p-(tert-Butyldimethylsiloxy)benzyl Chloride; 4-(tert-Butyldimethylsilyloxy)benzyl Chloride; 4-(Tert-Butyldimethylsilanyloxy)-benzylchlorid; 4-[(1,1-Dimethylethyl)dimethylsilyl]oxy]benzyl Chloride
EINECS	Contact for details

Quality Control

Our 4-(tert-Butyldimethylsilyloxy)Benzyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our production adheres to cGMP guidelines where applicable, ensuring reliability for critical applications in pharmaceutical development and advanced synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.