Description

4-(tert-Butyldimethylsiloxy)Benzyl Alcohol is a versatile organosilicon-protected benzyl alcohol derivative, serving as a crucial synthetic intermediate in advanced organic synthesis. Its primary value lies in the tert-butyldimethylsilyl (TBDMS) protecting group, which offers exceptional stability under a wide range of reaction conditions, enabling selective transformations. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity building blocks for complex molecule assembly.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for protecting alcohol functionalities during multi-step syntheses.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and plant growth regulators that require silicon-containing motifs.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing silicon-based components used in display and electronic materials.
• Polymer & Resin Modification: Employed to introduce siloxy-benzyl functional groups into polymer chains, altering physical and chemical properties.
• Organic Synthesis Reagent: A valuable reagent in academic and industrial R&D for constructing complex natural products and novel chemical entities.
• Flavor & Fragrance Ingredient Synthesis: Intermediate for creating specific aromatic compounds where the protected alcohol group is necessary.

Basic Information

Product Name	4-(tert-Butyldimethylsiloxy)Benzyl Alcohol
CAS No.	138585-08-7
Molecular Formula	C13H22O2Si
Molecular Weight	238.40 g/mol
Synonyms	4-[(tert-Butyldimethylsilyl)oxy]benzyl Alcohol; 4-(TBDMSO)Benzyl Alcohol; p-[(tert-Butyldimethylsilyl)oxy]benzyl Alcohol; 4-(tert-Butyldimethylsilyloxy)benzenemethanol; Benzenemethanol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-; 4-Hydroxymethylphenyl tert-butyldimethylsilyl ether; TBDMS Protected 4-Hydroxybenzyl Alcohol
EINECS	Contact for details

Quality Control

Our 4-(tert-Butyldimethylsiloxy)Benzyl Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP standards where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.