Description

2-(T-Butyldiphenylsilanyloxy)Ethanol is a versatile organosilicon-protected alcohol intermediate, widely recognized for its role in sophisticated organic synthesis. Its primary value lies in providing a robust, orthogonal protecting group for primary alcohols, enabling complex multi-step reactions in sensitive molecule construction. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for peptide synthesis, nucleoside chemistry, and the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly for protecting hydroxyl groups during multi-step API manufacturing.
• Peptide Synthesis: Used to protect the side-chain hydroxyl groups of amino acids like serine and threonine in solid-phase and solution-phase peptide synthesis.
• Nucleoside & Nucleotide Chemistry: Employed in the protection of sugar hydroxyls during the synthesis of modified nucleosides and oligonucleotides for antiviral and anticancer agents.
• Agrochemical Synthesis: Serves as a protected intermediate in the production of advanced herbicides, fungicides, and plant growth regulators.
• Material Science Research: Utilized in the development of novel silicon-containing polymers, dendrimers, and surface-modifying agents.
• Asymmetric Synthesis: Acts as a chiral auxiliary or a protected chiral alcohol precursor in stereoselective catalytic reactions.
• Cross-Coupling Reactions: Functions as a stable substrate in palladium-catalyzed cross-coupling reactions, such as Suzuki or Stille couplings, where the TBDPS group remains intact.

Basic Information

Product Name	2-(T-Butyldiphenylsilanyloxy)Ethanol
CAS No.	138499-16-8
Molecular Formula	C18H24O2Si
Molecular Weight	300.47 g/mol
Synonyms	2-[(tert-Butyldiphenylsilyl)oxy]ethanol; 2-(tert-Butyldiphenylsiloxy)ethanol; Ethanol, 2-[(1,1-dimethylethyl)diphenylsilyl]oxy]-; 2-Hydroxyethyl tert-butyldiphenylsilyl ether; TBDPS-O-(CH2)2OH; 2-O-TBDPS-ethanol; tert-Butyldiphenyl(2-hydroxyethoxy)silane
EINECS	Contact for details

Quality Control

Our 2-(T-Butyldiphenylsilanyloxy)Ethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our production adheres to cGMP principles where applicable, ensuring consistency and reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.