Description

(3S)-Tetrahydrofuranylsuccinimidyl-Carbonate is a specialized, high-purity chemical intermediate designed for advanced synthetic applications. This compound matters as a key reagent for introducing the tetrahydrofuranyloxycarbonyl (THFOC) protecting group, offering distinct selectivity and stability advantages in complex multi-step syntheses. It is primarily needed by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs), peptides, and other fine chemicals where precise stereochemistry is critical.

Application

• Pharmaceutical Intermediate Synthesis: A crucial building block for the production of complex, stereochemically defined active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used as an amine-protecting group reagent in solid-phase and solution-phase peptide synthesis.
• Protecting Group Chemistry: Serves as a reagent for introducing the THFOC group, which provides an alternative to Boc and Fmoc with specific cleavage profiles.
• Bioconjugation: Facilitates the controlled modification of biomolecules, such as proteins and antibodies, for drug delivery and diagnostic applications.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable manufacture of high-value fine chemicals.
• Academic & Industrial Research: A valuable tool for medicinal chemists and researchers exploring new synthetic methodologies and compound libraries.

Basic Information

Product Name	(3S)-Tetrahydrofuranylsuccinimidyl-Carbonate
CAS No.	138499-08-8
Molecular Formula	C10H13NO6
Molecular Weight	243.21 g/mol
Synonyms	THFOC-OSu; (3S)-Tetrahydro-3-furanyl (2,5-dioxo-1-pyrrolidinyl) carbonate; 1-[(Tetrahydro-3-furanyloxy)carbonyloxy]-2,5-pyrrolidinedione; (3S)-THFOC-OSu; N-[(Tetrahydro-3-furanyloxy)carbonyloxy]succinimide; Succinimidyl (3S)-tetrahydro-3-furanyl carbonate; (S)-Tetrahydro-3-furanyl succinimidyl carbonate; 2,5-Dioxopyrrolidin-1-yl (3S)-oxolan-3-yl carbonate
EINECS	Contact for details

Quality Control

Our (3S)-Tetrahydrofuranylsuccinimidyl-Carbonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Products undergo rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to meet the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed in a dry environment to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.