Description

1H-Imidazole-4-Carboxylicacid,5-Mercapto-,Methylester(9Ci) is a specialized heterocyclic building block featuring both a carboxylic acid methyl ester and a thiol functional group, making it a versatile intermediate for advanced synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in pharmaceutical and agrochemical research where precise functional group manipulation is critical. It serves the needs of R&D chemists and process development scientists in the life sciences and fine chemical industries seeking to develop new active ingredients or functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those targeting enzymes or receptors where the imidazole-thiol motif is pharmacologically active.
• Agrochemical Research: Used in developing new fungicides, herbicides, or plant growth regulators that utilize heterocyclic cores for bioactivity.
• Ligand Synthesis: Serves as a precursor for creating chelating ligands in catalysis and metal-organic frameworks (MOFs) due to its nitrogen and sulfur donor atoms.
• Peptide Mimetics & Bioconjugation: The reactive thiol group enables site-specific modification of peptides, proteins, and other biomolecules for biochemical studies.
• Material Science: Potential monomer or cross-linker in the development of specialty polymers with unique electronic or adhesive properties.
• Chemical Biology Probes: Useful for creating activity-based probes to study enzymatic function or for fluorescent labeling applications.

Basic Information

Product Name	1H-Imidazole-4-Carboxylicacid,5-Mercapto-,Methylester(9Ci)
CAS No.	138428-69-0
Molecular Formula	C5H6N2O2S
Molecular Weight	158.18 g/mol
Synonyms	5-Mercapto-1H-imidazole-4-carboxylic acid methyl ester; Methyl 5-mercapto-1H-imidazole-4-carboxylate; 5-Thiol-1H-imidazole-4-carboxylic acid methyl ester; 4-Carbomethoxy-5-mercaptoimidazole; 5-Mercaptoimidazole-4-carboxylic acid methyl ester; 1H-Imidazole-4-carboxylic acid, 5-mercapto-, methyl ester
EINECS	Contact for details

Quality Control

Our production of 1H-Imidazole-4-Carboxylicacid,5-Mercapto-,Methylester(9Ci) adheres to strict internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We employ validated analytical methods, including HPLC, NMR, and MS, to guarantee the integrity of this sensitive intermediate. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent oxidation of the thiol group. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.