Description

(6Ar-Trans)-1-[(tert-Butyl)Dimethylsilyloxy is a high-purity, protected intermediate of significant value in advanced organic synthesis. Its primary importance lies in its role as a versatile building block for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for chemists and manufacturers in the fine chemical, agrochemical, and life science industries who require reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for complex heterocyclic or steroidal compounds.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where its protected functionality allows for selective chemical transformations.
• Academic & Contract Research: Serves as a critical reagent in university and CRO laboratories for methodological development and the synthesis of novel chemical entities for biological screening.
• Material Science Research: Potential building block for creating specialized organic molecules used in advanced materials, such as liquid crystals or organic semiconductors.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production, where consistent quality is paramount.

Basic Information

Product Name	(6Ar-Trans)-1-[(tert-Butyl)Dimethylsilyloxy
CAS No.	138285-38-8
Molecular Formula	C16H28OSi
Molecular Weight	264.48 g/mol
Synonyms	1-[(1,1-Dimethylethyl)dimethylsilyl]oxy-6ar-trans; (6aR-trans)-1-[(tert-Butyl)dimethylsilyl]oxy; tert-Butyldimethyl((6aR-trans)-1-yloxy)silane; TBDMS-protected trans intermediate; (6aR-trans)-1-TBDMS ether; 1-(tert-Butyldimethylsilyloxy)-6ar-trans; (6aR-trans)-1-[(tert-Butyl)dimethylsilyl]oxy derivative
EINECS	Contact for details

Quality Control

Our (6Ar-Trans)-1-[(tert-Butyl)Dimethylsilyloxy is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and isomeric integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Isomeric Purity (HPLC)	≥ 98.0% (6aR-trans)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.