Description

(6Ar-Trans)-1-[(tert-Butyl)Dimethylsilyloxy]-6A,7,8 is a high-purity, protected intermediate compound of significant interest in advanced organic synthesis. Its value lies in its role as a key building block for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for chemists and organizations engaged in the synthesis of novel active pharmaceutical ingredients (APIs), fine chemicals, and specialized materials where precise stereochemistry and functional group protection are critical.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Organic Synthesis Research: Used in academic and industrial R&D for developing new synthetic methodologies and exploring novel chemical spaces.
• Fine Chemical Production: Serves as a specialized intermediate in the manufacture of high-value, low-volume fine chemicals and custom synthesis projects.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production scales.
• Stereoselective Synthesis: Utilized in reactions where control of the trans configuration at the 6A,7,8 position is required for target molecule assembly.
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) group provides a stable protecting moiety for alcohols during complex synthetic sequences.

Basic Information

Product Name	(6Ar-Trans)-1-[(tert-Butyl)Dimethylsilyloxy]-6A,7,8
CAS No.	138285-36-6
Molecular Formula	C16H30O2Si
Molecular Weight	282.50 g/mol
Synonyms	(6aR,7R,8R)-1-[(tert-Butyldimethylsilyl)oxy]-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-6-one; 1-[(1,1-Dimethylethyl)dimethylsilyl]oxy-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-6-one, (6aR-trans)-; (6aR,7R,8R)-1-((tert-Butyldimethylsilyl)oxy)-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-6-one; TBDMS-protected trans-diol derivative; 138285-36-6
EINECS	Contact for details

Quality Control

Our (6Ar-Trans)-1-[(tert-Butyl)Dimethylsilyloxy]-6A,7,8 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced to meet the exacting standards of pharmaceutical intermediate suppliers, specific grade requirements (e.g., for GMP applications) can be discussed and validated.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can compromise product integrity. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.